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Bio-Rad
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Image Search Results
Journal: Scientific Reports
Article Title: scATAC-Seq reveals heterogeneity associated with spermatogonial differentiation in cultured male germline stem cells
doi: 10.1038/s41598-022-25729-7
Figure Lengend Snippet: Profiling chromatin accessibility of germline stem cells (GSCs) after retinoic acid (RA) treatment. ( a ) Schematic of experimental design. The workflow of sample collection after RA treatment and scATAC-seq to measure single nuclei accessibility on the BioRad SureCell ATAC-Seq platform. ( b ) Violin plot of TSS enrichment scores. ( c ) Ridge plot of number of unique fragments. ( d ) Pairwise comparison of gene scores between CTRL and RA-treated samples. The volcano plots show the differential gene score against the − log10(P value) of all investigated genes; each dot represents one gene. Red dots indicate the genes with FDR < 0.05 and log2FC > 0.1 or < -0.1. ( e ) Ridge plots of gene activity of SSC self-renewal and differentiation genes in GSCs with (blue) and without (red) RA treatment.
Article Snippet: The workflow of sample collection after RA treatment and scATAC-seq to measure single nuclei accessibility on the
Techniques: Activity Assay